Short Course in FBAT/PBAT at Harvard School of Public Health
Course Date and Location: June 11-12, 2007 at the Harvard School of
Public Health, Boston MA.
Course Organizers and Faculty: Nan Laird and Christoph Lange. Department
of Biostatistics, Harvard School of Public Health
Description:
The increasing availability of genetic marker data, especially SNP’s, has
made investigations of genetic associations between marker data and
disease commonplace. This course will focus on family based designs for
association studies; these designs use information on affected individuals
and their relatives, most commonly parents and/or siblings. Family based
designs are attractive in that they test for both association and linkage
thus avoiding difficulties with population stratification and admixture.
In addition, the population information in the data can be used for model
building and screening. This course will give a very brief introduction to
the basic concepts of genetic association in general, and family based
designs in particular. The focus of the course is on the FBAT/PBAT
methodology and how to use the packages. An overview of the topics
discussed can be found in Laird NM and Lange C “Family Based Designs in
the Age of Large-Scale Gene-Association Studies,” Nature Reviews/Genetics,
2006, 7:385-394.
The orientation of the course is practical rather than theoretical. It
combines lectures and computer tutorials with hands on data analysis using
the FBAT and PBAT packages. Both packages can be accessed from the
FBAT/PBAT web pages http://www.biostat.harvard.edu/~clange/default.htm and
http://www.biostat.harvard.edu/~fbat/default.html. P2BAT is available
through the R-package that can be downloaded at http://www.r-project.org.
The GoldenHelix PBAT version will be posted on the course web-page 2 weeks
before to the course. A special website will be created for the course
so that all course materials will be available there. Note: Both
GoldenHelix PBAT and P2BAT will be taught in this course.
Intended audience: This course is intended for clinicians,
epidemiologists, data analysts, geneticists, and statisticians involved in
the analysis of genetic data. Familiarity with genetic concepts as well
as background in basic statistics at the level of linear/logistic
regression is highly desirable. Participants are encouraged to bring
their own data sets; check the FBAT web page for details on file format.
We also strongly recommend that participants read the manuals before
attending the course.
Application, Registration and Fees. The course fee is $400.00; this
covers course materials, coffee breaks and two lunches. An optional
course dinner will be held on Monday night for an additional $50.
Applicants will be accepted on a first come first serve basis; the course
is limited to 45 participants. Full time doctoral students may obtain a
reduced fee of $150 (plus $50 for the optional course dinner) with a
letter certifying student status from your institution. Please fill out
the Registration Form (Follows Preliminary Schedule Below) and return via
email to Jelena T. Follweiler ([log in to unmask]).
To download the course information and Registration Form, go to one of the
websites listed above.
Application Deadline: Monday, May 7, 2007.
GoldenHelix Travel Scholarship: Golden Helix will award a scholarship to
cover the travel expenses of one course participant. Please visit
http://www.goldenhelix.com/pbat.html and click on the "PBAT Short Course
scholarship" link at the top of the page for details.
Application, Registration and Fees.
Preliminary Schedule
Monday 6/11
8:00- 8:30 Registration
8:30-10:00 Basic concepts I
10:30-10:15 Break
10:30-11:15 Basic concepts II
11:15-12:15 FBAT computer tutorial/Presentation
12:15- 1:15 Lunch
1:15- 2:30 Multiple markers: haplotypes and the multimarker test
2:30- 2:45 Break
2:45- 3:30 Complex phenotypes: Multiple Phenotypes (FBAT GEE) and Time
to Onset: FBAT-LOGRANK
3:30--- FBAT/PBAT Computer tutorial/Presentation
6:00 Optional Course dinner
Tuesday 6/12
8:30-10:00 Screening and model building using the population information:
The conditional mean model. Time to Onset
(FBAT-Flemming Harrington) and Multiple Measures (FBAT-PC)
10:00-10:15 Break
10:15-12:30 PBAT Computer tutorial/ Presentation
12:30- 1:30 Lunch
1:30- 3:00 Whole genome scans; screening with trios
3:00- 3:15 Break
3:15- 5:00 PBAT Computer tutorial/ Presentation
REGISTRATION FORM
Short Course on FBAT and PBAT
June 11-12, 2007, Harvard School of Public Health, Boston MA 02115
Please email completed form to Jelena T. Follweiler
([log in to unmask]). Do NOT send registration fee until your
acceptance has been confirmed. Once you have been accepted, the full fee
is required to hold your place. Please note that once your application
has been accepted, you must also send the optional course dinner fee if
dinner is desired. Sorry, but credit cards cannot be accepted.
Name:
Affiliation/Address:
Email Address:
Position (e.g. M.D. in Psychiatry, Postdoc in Epidemiology, etc.):
Experience in Genetic Analysis, Family-Based Association Studies, etc.:
Previous Coursework in Statistics/Biostatistics:
Other Relevant Experience:
Software packages you are familiar with, INCLUDING FBAT and PBAT:
What do you hope to gain from attending this course?
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