JOB TITLE: Post-Doctoral Statistical Genetics Research Fellow
SALARY: £35100 - £38712
DEPARTMENT: Cardiology Dept, Ealing Hospital in conjunction with Dept
of Epidemiology Imperial College, National Heart and Lung Institute,
Imperial College, and Medical Genetics, Clinical Pharmacology and
Discovery Medicine (CPDM), GSK
ACCOUNTABLE TO: Professors Jaspal S Kooner and Vincent Mooser
Applications are invited for the post of Post-Doctoral Statistical
Genetics Research Fellow. The appointee will contribute to the analysis of
genome wide association data from the London Life Sciences Prospective
Population (LOLIPOP) study. The appointee will have experience in the
field of genetic epidemiology, with a proven track record of publications.
The appointee will be expected to develop a high quality research
programme, under the direction of the senior LOLIPOP and GSK
investigators.
The post will be jointly based in the Department of Cardiology at Ealing
Hospital, and GSK. The post-holder will collaborate extensively, and will
also hold honorary contracts, with Imperial College and GSK. The post is
funded by an unrestricted grant from GSK.
THE DEPARTMENT
The Department of Cardiology has over twenty staff involved in research
into the genetic and environmental factors underlying complex diseases
including metabolic syndrome, hypertension, diabetes and coronary artery
disease in UK Indian Asians and Northern Europeans. The Department is led
by Professor JS Kooner, who is supported by three Senior Lecturers (Dr
John Chambers, Dr Stuart Rosen, Dr Ranil De Silva). The Department works
in close collaboration with Imperial College, and in partnership with
Pharmaceutical and biotechnology companies.
The postholder will be based jointly at Ealing Hospital and GSK, and will
also benefit from close collaboration with the many intellectual resources
of Imperial College, including a wide range of seminars and lectures, and
the advice and expertise of the National Heart and Lung Institute, and the
Department of Epidemiology and Public Health.
THE PROJECT
Coronary Heart Disease (CHD) mortality is 2-fold higher in UK Indian
Asians than Northern Europeans, and is not accounted for by recognised
coronary risk factors. The London Life Sciences Population (LOLIPOP)
Research Programme (PIs Prof JS Kooner, Dr JC Chambers) is an
investigation of 30,000 Indian Asians and Europeans. This research
includes a cohort study aimed at identifying incident coronary heart
disease, type-2 diabetes mellitus, obesity, and chronic kidney disease in
the two populations. To date over 24,000 participants have been recruited
and characterised. Blood samples have been stored and participants are
being followed every 5 years for cardiovascular and other health events.
Key sub-studies have also been established and include;
i. LOLIPOP Genomics, to identify common genetic variants underlying
susceptibility to complex traits, including insulin resistance, type-2
diabetes, and atherosclerosis, using whole genome association approaches.
ii. LOLIPOP ?Omics?, to identify metabolomic, proteomic and transcriptomic
fingerprints linked with CHD in the two population groups.
iii. LOLIPOP Atherosclerosis, to identify factors associated with
subclinical atherosclerosis, and its progression, using quantitative
markers (EBCT, cIMT).
Genomic, metabolomic and proteomic assays are being completed as a
collaboration between the LOLIPOP investigators and GSK. 1500 genome wide
association scans have already been completed using the Affymetrix 500K
chip, and a further 1000 scans are expected over the next 6 months.
The results of LOLIPOP and its substudies will enable identification of
factors that contribute to increased CHD risk amongst Indian Asians, and
help develop effective diagnostic, therapeutic and preventive strategies
for CHD in Indian Asians that can be readily applied in clinical practice.
DUTIES & RESPONSIBILITIES:
In collaboration with clinical researchers, implement a data management
system for genotype and clinical data being collected.
In collaboration with genomics researchers, analyse the relationships
between genetic markers and phenotypes (clinical, metabolomic and
proteomic) associated with atherosclerosis, and other human disease.
Make a strong contribution to reporting study results, including writing
up for publication in peer-reviewed journals and presentations at seminars
and conferences
To plan and carry our research in accordance with the project aims
To maintain accurate and complete records of all findings
To present research findings to colleagues and at conferences
To conduct literature searches and reviews
To develop contacts and research collaborations within the Department and
wider academic community in order to further the project aims
To demonstrate an up to date knowledge of scientific literature in
research area
CONFIDENTIALITY
Information relating to patients, employees and business of the Trust must
be treated in the strictest confidence. Under no circumstances should
such information be discussed with any unauthorised person(s) or
organisations. Breaches of confidentiality may lead to disciplinary
action.
HEALTH AND SAFETY AT WORK
You are required to take reasonable care of the health and safety of
yourself and other persons who may be affected by your acts or omissions
at work and to co-operate with the Trust in adhering to statutory and
departmental safety regulations.
EQUAL OPPORTUNITIES
Ealing Hospital NHS Trust stands in opposition to all forms of less
favourable treatment accorded to employees or job applicants on the
grounds of race, age, sexual orientation, religion, disability,
nationality, martial status, HIV/AIDS status, trade union membership
and/or activity.
RISK MANAGEMENT
You are required to contribute to the control of risk and use the incident
reporting system to alert the Trust of incidents or near misses that may
compromise the quality of services.
CLINICAL GOVERNANCE
It is the duty of every employee to fulfil their individual clinical
governance responsibilities and their expected contribution to ensuring
that the Trust complies with benchmarked standards for quality of clinical
care.
This list is only an indication of the main tasks required to be
performed. It is not an exhaustive list of duties and responsibilities
and may be subject to amendments to take account of changing
circumstances. The Trust reserve the right that you may be required to
undertake such other duties and/or hours of work as may reasonably be
required of you commensurate with your grade at your normal place of work
or from another location within the Trust.
PERSON SPECIFICATION
Qualifications/Knowledge
Essential:
a PhD in statistical genetics or genetic epidemiology or related field
(statistics, epidemiology, population genetics, bioinformatics,
mathematics)
Experience
Essential:
experience of scientific computer programming
experience of data management and statistical analyses
Desirable:
experience of designing, and/or analysing data from, genetic association
studies
Skills/Abilities
Essential:
Ability communicate well in writing, person to person, and in seminar or
conference presentations
Ability to solve problems using innovative and flexible thinking
Ability to work autonomously and take responsibility
Ability to work proactively within an agreed programme
Contact Details
Please send CV and cover letter to:
Professor Jaspal S Kooner MD FRCP
Professor of Clinical Cardiology and Consultant Cardiologist
National Heart & Lung Institute
Imperial College Faculty of Medicine
Hammersmith Hospital Campus
Du Cane Rd,
London
W12 ONN, UK
Tel: +44 20 8383 3037 (PA, Hammersmith)
Fax: +44 20 8967 5884
Mobile: +44 7970 666777
email: [log in to unmask]
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