A three day short course "Genetics Association Studies and Mendelian-
Randomization" will take place in the Department of Social medicine,
University of Bristol from 11th-13th July 2007.
For more information and details of how to book please see
http://www.epi.bris.ac.uk/shortc/genetics.htm#mendel
Who the course is intended for: The course is designed for medical
researchers who already have an understanding of epidemiological concepts
and methods. Participants should have at least a basic knowledge of
statistics, and genetics knowledge at least to the level of our Genetics
for Epidemiologists Short Course.
Course content: Topics to be covered include: Study design, statistical
analysis, confounding by population structure, indirect associations-
linkage disequilibrium, haplotypes, population heterogeneity, replication
of findings and sample size issues, meta-analysis, biobanks, candidate gene
versus whole genome association approach, interpreting results, detecting
and minimizing genotyping error, introduction to Mendelian randomization,
types of inference in Mendelian randomization, limitations of Mendelian
randomization, future of genetics in public health.
Suggested pre-course reading: Cordell HJ and Clayton DG. Genetic
association studies. Lancet 2005;1121-31.
Hattersley AT and McCarthy MI. What makes a good genetic association study?
Lancet 2005;1315-23.
Davey Smith G, Ebrahim S. "Mendelian randomization": Can genetic
epidemiology contribute to understanding environmental determinants of
disease? Int J Epidemiol 2003;32:1-22.
Teaching time: Eighteen hours with formal lectures, practical sessions, and
group discussion work.
Course fee: £450.
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