See below for details of 2 short courses coming up in the area of
genetic epidemiology.
Heather Cordell
-----------------------------------------
*Two weeks of genetic epidemiology courses in Rotterdam*
Organized by the Netherlands Institute for Health Sciences (Nihes)
Location: Erasmus MC, Rotterdam, The Netherlands
March 19-23, 2007: Advances in Population-based Studies of Complex
Genetic Disorders
March 26-30, 2007: Model-free Linkage and Pedigree-based Association
Analysis of Complex Traits
Outline of the courses:
*ADVANCES IN POPULATION-BASED STUDIES OF COMPLEX GENETIC DISORDERS*
Dates: March 19-23, 2007
Location: Erasmus MC, Rotterdam, The Netherlands
Instructors: Prof. Cornelia M. van Duijn (Erasmus MC, Rotterdam), Dr
David Evans (Wellcome Trust Centre for Human Genetics, Oxford), Susan
Service (University of California, Los Angeles), Dr Cecile Janssens
(Erasmus MC, Rotterdam), Dr Yurii Aulchenko (Erasmus MC, Rotterdam)
This 5-day advanced course in statistical genetics aims to give an
overview of new developments in the field of population-based research
for those with a background in genetic epidemiology and/or statistics.
In the first part of the course, genome-wide association (GWA) analysis
will be covered. This part will include genetics data quality control,
practical GWA analysis of quantitative and binary traits, methods to
detect and correct for stratification, and modeling of epistasis. In the
second part we will concentrate on linkage disequilibrium structure of
human genome (the HapMap project) and methods for analysis of selected
regions, including the coalescent. Analysis of multiple correlated
outcomes will be also be considered. Finally, we will discuss the
perspectives for genetic testing in clinical practice.
A major part of the teaching programme consists of hands-on exercises
using computer programs that are available on the Internet.
http://www.nihes.nl/site/index.php?id=482,541,0,0,1,0&course_id=54
*MODEL-FREE LINKAGE AND PEDIGREE-BASED ASSOCIATION ANALYSIS OF COMPLEX
TRAITS*
Dates: March 26-30, 2007
Location: Erasmus MC, Rotterdam, The Netherlands
Instructors: Prof. Heather Cordell (University of Newcastle), Prof.
Peter Holmans (Cardiff University), Dr Yurii Aulchenko (Erasmus MC,
Rotterdam), Fan Liu (Erasmus MC, Rotterdam)
This course is organized for researchers with a background in genetic
epidemiology and/or statistics. The focus of the course is on
theoretical background and practical issues in model-free linkage
studies of complex genetic traits. Both qualitative outcomes (e.g.
diseases) as well as quantitative (continuous) traits are addressed. For
quantitative traits Haseman-Elston methods and maximum likelihood
estimation of variance components are discussed. Other issues covered
are the inclusion of covariates, extreme sampling, and the
generalization of methods based on sibling pairs to other pedigree
structures.
Family-based association studies, also in the context of whole-genome
association analysis, will be considered, including total tests which
utilise between- and within family variation, and also
Transmission-Disequilibrium-like tests.
The teaching program consists mainly of hands-on exercises using
computer programs that are available on the Internet.
http://www.nihes.nl/site/index.php?id=482,541,0,0,1,0&course_id=56
*Further information*
Application deadline:
two weeks before the start of the course
You can apply on-line at:
http://www.nihes.nl/site/index.php?id=483,826,0,0,1,0
Please check with Nihes office if you are eligible for a discount (up to
50%! -- e.g. CMSB and GeNeYouS members)
Administrative information:
http://www.nihes.nl
More information on the scientific content of the courses:
contact Yurii Aulchenko at [log in to unmask]
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