Hi there,
I am refining a lectin-carbohydrate complex. The electron density clearly shows that a mixture of alpha- and beta-anomers of the sugar have bound in the crystal. How can i generate appropriate restraints for the carbohydrate with alternative conformations (i.e. alpha- and beta-anomer)? At the moment, i use the beta-anomer dictionary from refmac for refinement. Consequently, both conformations are pushed in the beta-position.
Greetings, David
--
Der GMX SmartSurfer hilft bis zu 70% Ihrer Onlinekosten zu sparen!
Ideal für Modem und ISDN: http://www.gmx.net/de/go/smartsurfer
|