Short Course in FBAT/PBAT at Harvard School of Public Health
Course Date and Location: June 11-12, 2007 at the Harvard School of Public
Health, Boston MA.
Course Organizers and Faculty: Nan Laird and Christoph Lange. Department
of Biostatistics, Harvard School of Public Health
Please note that we offer a travel scholarship for this course
Description: The increasing availability of genetic marker data, especially
SNP's, has made investigations of genetic associations between marker data and
disease commonplace. This course will focus on family based designs for
association studies; these designs use information on affected individuals and
their relatives, most commonly parents and/or siblings. Family based designs
are attractive in that they test for both association and linkage thus avoiding
difficulties with population stratification and admixture. In addition, the
population information in the data can be used for model building and
screening. This course will give a very brief introduction to the basic
concepts of genetic association in general, and family based designs in
particular. The focus of the course is on the FBAT/PBAT methodology and how to
use the packages. An overview of the topics discussed can be found in Laird NM
and Lange C "Family Based Designs in the Age of Large-Scale Gene-Association
Studies," Nature Reviews/Genetics, 2006, 7:385-394.
The orientation of the course is practical rather than theoretical. It combines
lectures and computer tutorials with hands on data analysis using the FBAT and
PBAT packages. Both packages can be accessed from the FBAT/PBAT web pages
http://www.biostat.harvard.edu/~clange/default.htm and
http://www.biostat.harvard.edu/~fbat/default.html. P2BAT is available through
the R-package that can be downloaded at http://www.r-project.org. The
GoldenHelix PBAT version will be posted on the course web-page 2 weeks before
to the course. A special website will be created for the course so that all
course materials will be available there. Note: Both GoldenHelix PBAT and
P2BAT will be taught in this course.
Intended audience: This course is intended for clinicians, epidemiologists,
data analysts, geneticists, and statisticians involved in the analysis of
genetic data. Familiarity with genetic concepts as well as background in basic
statistics at the level of linear/logistic regression is highly desirable.
Participants are encouraged to bring their own data sets; check the FBAT web
page for details on file format. We also strongly recommend that participants
read the manuals before attending the course.
Application, Registration and Fees. The course fee is $400.00; this covers
course materials, coffee breaks and two lunches. An optional course dinner
will be held on Monday night for an additional $50. Applicants will be accepted
on a first come first serve basis; the course is limited to 45 participants.
Full time doctoral students may obtain a reduced fee of $150 (plus $50 for the
optional course dinner) with a letter certifying student status from your
institution. Please fill out the Registration Form (Follows Preliminary
Schedule Below) and return via email to Jelena T. Follweiler
([log in to unmask]). To download the course information and
Registration Form, go to one of the websites listed above.
Application Deadline: Monday, May 7, 2007.
GoldenHelix Travel Scholarship: Golden Helix will award a scholarship to
cover the travel expenses of one course participant. Please visit
http://www.goldenhelix.com/pbat.html and click on the "PBAT Short Course
scholarship" link at the top of the page for details.
Application, Registration and Fees.
Preliminary Schedule
Monday 6/11
8:00- 8:30 Registration
8:30- 10:00 Basic concepts I
10:30-10:15 Break
10:30-11:15 Basic concepts II
11:15-12:15 FBAT computer tutorial/Presentation
12:15- 1:15 Lunch
1:15- 2:30 Multiple markers: haplotypes and the multimarker test
2:30- 2:45 Break
2:45- 3:30 Complex phenotypes: Multiple Phenotypes (FBAT GEE) and Time
to Onset: FBAT-LOGRANK
3:30--- FBAT/PBAT Computer tutorial/Presentation
6:00 Optional Course dinner
Tuesday 6/12
8:30-10:00 Screening and model building using the population information:
The conditional mean model. Time to Onset (FBAT-Flemming
Harrington) and Multiple Measures (FBAT-PC)
10:00-10:15 Break
10:15-12:30 PBAT Computer tutorial/ Presentation
12:30-1:30 Lunch
1:30- 3:00 Whole genome scans; screening with trios
3:00- 3:15 Break
3:15- 5:00 PBAT Computer tutorial/ Presentation
REGISTRATION FORM
Short Course on FBAT and PBAT June 11-12, 2007, Harvard School of Public
Health, Boston MA 02115 Please email completed form to Jelena T. Follweiler
([log in to unmask]). Do NOT send registration fee until your acceptance
has been confirmed. Once you have been accepted, the full fee is required to
hold your place. Please note that once your application has been accepted, you
must also send the optional course dinner fee if dinner is desired. Sorry, but
credit cards cannot be accepted.
Name:
Affiliation/Address:
Email Address:
Position (e.g. M.D. in Psychiatry, Postdoc in Epidemiology, etc.):
Experience in Genetic Analysis, Family-Based Association Studies, etc.:
Previous Coursework in Statistics/Biostatistics:
Other Relevant Experience:
Software packages you are familiar with, INCLUDING FBAT and PBAT:
What do you hope to gain from attending this course?
|