Dear Users,
I am new with the Winbugs syntax and I want to estimate a non-linear
pharmacokinetic model with the following equation:
C_i,j= (D*Ke*Ka/(Cl*Ka-Ke)) * (exp(-ke*t)-exp(-ka*t) ) + ei .
where C_i,j is drug concentration in time(j) and case(i), D is drug dose, Cl
is the clearance, ke and ka are a absorption and excretion constants, t is
time (25 periods), ei is the model error (normal).
The target is predict a new case using only first part of data (First 5 to 10
time periods).
I think that is useful use pkbugs to this type of models (PK),
but I do not have experience.
Please, any code or idea in how to compute this code will be very welcome.
Thanks for your time and attention in advanced
Prof. Toni Monleon Getino
Dep Statistics
University of Barcelona
Spain
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