Dear All,
I m not so familiar with bayesian inference and some issues have arise in my
mind.
Let's suppose, we want to conduct a double blind, randomised, placebo
control study. The sample size calculation I performed indicated 95 patents
per arm (bayesian approach).
Is it possible to adopt a sequential Bayesian desing for this study? My
major concern is the unblinding each time the stoping rules shoule be tested
in interim analysis.
Any suggestions or references are more than wellcome.
Regards,
Evie Delicha
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