> Could you give me any good links or references to tensor-based morphometry
> methods. I tried web search, but could find anything specific :-(. Thank
> you.
Morphometry is an enormous field and the approach you adopt should be specific
to the question that you want to ask and the assumptions you have about the
data. The stuff that I have mentioned in papers etc a few years ago is far
from being the state-of-the art, and was written when I really didn't know
any better. A couple of years back, there was a special issue of NeuroImage
that covers the more recent developments in morphometry:
NeuroImage Volume 23, Supplement 1, Pages CO2-S299 (2004)
Mathematics in Brain Imaging
Edited by P.M. Thompson, M.I. Miller, T. Ratnanather, R.A. Poldrack and T.E.
Nichols
Most of the articles in this issue are not so accessable to
non-mathematicians, but you may want to check out the papers of e.g. John
Csernansky for ideas that are easier to digest. There is also stuff on
cortical folding patterns etc by people such as J-F Mangin that are easier to
follow.
There are not really any tools in SPM5 to do TBM well, so you'll need to track
down and modify the relevant software yourself. The segment button in SPM5
will produce a deformation field that you could do stats on, but as the
deformation is only parameterised by about 1000 basis function coefficients,
then you won't find any differences that that can be especially precisely
localised. I have started to work on much better methods than the ancient
ideas used for warping in SPM, but it will be a while before they are ready
for release.
Examples of papers that use various TBM-like approach are:
Christian Gaser, Igor Nenadic, Bradley R. Buchsbaum, Erin A. Hazlett and
Monte S. Buchsbaum. "Deformation-Based Morphometry and Its Relation to
Conventional Volumetry of Brain Lateral Ventricles in MRI". NeuroImage
13:1140-1145 (2001).
C. Studholme, V. Cardenas, N. Schuff, H. Rosen, B. Miller, and M. Weiner.
Detecting spatially consistent structural differences in Alzheimer’s and
Fronto temporal dementia using deformation morphometry. In Proceedings of 4th
International Conference on Medical Image Computing and Computer Assisted
Interventions, 2001, pages 41–48, 2001, Springer-Verlag, ISBN 3-540-42697-3.
C. Studholme, V. Cardenas, A.Maudsley, M. Weiner, “An Intensity Consistent
Approach to the Cross Sectional Analysis of Deformation Tensor Derived Maps
of Brain Shape”, In Proceedings of 5th International Conference on Medical
Image Computing and Computer Assisted Interventions, 2002, pages 492-499,
2002, Springer-Verlag.
Kipps CM, Duggins AJ, Mahant N, Gomes L, Ashburner J & McCusker EA (2005):
"Progression of structural neuropathology in preclinical Huntington's disease:
a tensor based morphometry study". Journal of Neurology, Neurosurgery and
Psychiatry 76(5):650-655.
Best regards,
-John
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