Thanks Russ (and Elisabeth).
That was my impression. I just don't hear the problem posed in terms
of lesion or TMS data. I'm also assuming it would require proof of
the obverse, namely that patients with lesions somewhere else don't
exhibit the deficit.
regards,
Greig
On 28/02/2006, at 2:59 AM, Russ Poldrack wrote:
> Grieg - this seems to run into the same problems as reverse
> inference with imaging data. again here, the issue is how selective
> the deficit is to the particular cognitive process, which requires
> that patients with the same lesions have been tested with lots of
> other tasks.
> cheers
> russ
>
> On Feb 27, 2006, at 4:49 AM, Greig de Zubicaray wrote:
>
>> Dear all,
>>
>> Just a quick question for the neuroimaging community.... Having
>> read Russ Poldrack's recent paper in TICS on the problems inherent
>> in using neuroimaging data to support reverse inference (I agree
>> with Russ), I was wondering what the views about lesion and TMS
>> data were? Lesion and TMS data are often described as being
>> capable of demonstrating causality in cognitive neuroscience
>> studies. So, given evidence that a lesion (or disruption) to
>> region X impairs, say, phonological processing permanently (or
>> temporarily), can this evidence be used to support a reverse
>> inference that region X was probably engaged in similar processing
>> during performance of a different task with a putative
>> phonological component?
>>
>> For the record, the question is motivated by reviewer comments
>> that quite literally (and oddly) focussed on a discussion of
>> mechanisms potentially involved in a task and not directly under
>> investigation in one of our studies. Mechanisms we stated clearly
>> that our data could not adjudicate between. We cited complementary
>> neuroimaging, lesion and TMS data demonstrating the problem of
>> attributing attention or memory selectively to the IPL. The
>> reviewers chose to focus solely upon the neuroimaging data we
>> cited and its inability to support reverse inference. Not one
>> mention of the lesion or TMS data.
>>
>> Thoughts?
>>
>> regards,
>>
>> Greig
>>
>> __
>> Dr Greig de Zubicaray
>> Senior Research Fellow
>> Centre for Magnetic Resonance
>> University of Queensland, QLD 4072, Australia
>> Tel: (+617) 3365 4100 (Office)
>> (+617) 3365 4250 (B106, Ritchie Building)
>> Fax: (+617) 3365 3833
>> Staff Page: http://www.cmr.uq.edu.au/CMR_Staff_Zubicaray.htm
>> fMRI Lab Page: http://www.cmr.uq.edu.au/Research_Imaging_fMRI.htm
>
> ---
> Russell A. Poldrack, Ph.d.
> Associate Professor
> UCLA Department of Psychology
> Franz Hall, Box 951563
> Los Angeles, CA 90095-1563
>
> phone: 310-794-1224
> fax: 310-206-5895
> email: [log in to unmask]
> web: www.poldracklab.org
>
>
>
__
Dr Greig de Zubicaray
Senior Research Fellow
Centre for Magnetic Resonance
University of Queensland, QLD 4072, Australia
Tel: (+617) 3365 4100 (Office)
(+617) 3365 4250 (B106, Ritchie Building)
Fax: (+617) 3365 3833
Staff Page: http://www.cmr.uq.edu.au/CMR_Staff_Zubicaray.htm
fMRI Lab Page: http://www.cmr.uq.edu.au/Research_Imaging_fMRI.htm
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