Hi Ashik,
Do you mean global scaling or spatial normalization?
For SPECT studies, you need to run both.
I have obtained stronger statistics in the final result if I mask out scalp
activity for both spatial normalization and global scaling. See my Masks
toolbox at www.anzsnm.org.au/ftp/idl/Masks.htm
Good Luck
Leighton
Leighton Barnden PhD
Medical Scientist
Nuclear Medicine, The Queen Elizabeth Hospital
Woodville Road, Woodville
SA 5011, Australia
ph. +61 8 8222 6438
> Dear SPMrs,
> Using brain perfusion images[ 99mTc-HMPAO SPECT in dementia
> patients group],
> is it justified to run SPM-without global normalization?
>
> If it possible,please provide some general instructions how
> to do that.
>
> Thanking you,
> Ashik.
> Department of Nuclear Medicine,
> Osaka University,
> Osaka,Japan
>
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