> There is an option in the SPM normalize function to use a weighting
> mask. From the description of the function, it appears that this is used
> in the case of lesioned brains to exclude areas that should not be used
> to estimate the normalization parameters.
>
> Is there a way to use this weighting to improve the quality of
> normalization in specific regions rather than the whole brain, i.e. by
> using a basal ganglia mask for example to get better normalization
> specifically in that location, paying less attention to the rest of the
> brain?
It probably wouldn't be a good idea to try this, as you are very likely to get
cought in local minima. In SPM, spatially normalising images with a small
field of view tends not to work incredibly well.
Best regards,
-John
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