SEMINAR: RSS South Wales Local Group
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The next seminar of the South Wales local group of the RSS is on Wednesday 14th December at 5:00pm (4:30pm for tea/coffee and mince pies) at the Conference Room, Local Government Data Unit - Wales, 8 Columbus Walk, Cardiff.
Directions to the Data Unit can be found by following this link: http://www.dataunitwales.gov.uk/eng/ContactUs.asp
The speaker will be Andrew Garrett, Quintiles. "Switching between superiority and non-inferiority - is a coherent approach possible?".
The CHMP Points to Consider (Guideline) on Switching between Superiority and Non-inferiority is directed towards ensuring the most appropriate interpretation of the data from a randomised clinical trial at the time of analysis. Specifically it focuses upon the interpretation of the estimated confidence limits of the treatment difference. However given that it is only the conclusion drawn from the values of the confidence limits that may differ and not the confidence interval itself, there are some statistical conventions relating to the analysis of superiority and non-inferiority trials that must be addressed when estimating confidence limits. This talk will examine some the areas where the standard approach to statistical analysis might differ between superiority and non-inferiority. In each case, practical recommendations will be made to ensure that the approach to switching between superiority and non-inferiority is coherent.
* Confidence interval coverage
* Choice of analysis populations
* Accounting for missing values
* Covariate adjustment
ALL ARE WELCOME
Rebecca Cannings-John
Statistician
Cardiff University
Department of General Practice
Room 2F 15
Cardigan House
Wales College of Medicine
Heath Park
Cardiff
CF14 4XN
Tel: 029 2074 5105
www.uwcm.ac.uk/study/medicine/general_practice
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