Now is an extremely exciting time for the study of human genetic 
variation. The Wellcome Trust Sanger Institute (WTSI) is a world leader 
in human genomics and genome informatics. We are consolidating and 
expanding an ambitious programme of research characterising Copy Number 
Variation in the human genome (Conrad et al., Nature Genetics, in 
press) and integrating this knowledge into disease association studies. 
This programme combines large-scale experimental data generation, on a 
variety of platforms, with sophisticated data analyses.

Statistician/Mathematical Biologist Ref NA1028

In collaboration with David Clayton at the Juvenile Diabetes Research 
Foundation/Wellcome Trust Diabetes and Inflammation Laboratory in 
Cambridge, we are seeking a highly talented and motivated post-doctoral 
researcher with a background in Mathematical Biology or Statistics who 
may have a proven track record or who has demonstrated exceptional 
potential during a recently-completed PhD. A biological background is 
not strictly necessary. Experience with change-point models or 
analysing microarray data would be an advantage. The successful 
applicant will be involved in the design and analysis of genetic and 
functional studies of copy number variation, including the development 
of novel algorithms for identifying copy number variation from 
microarray data and assessing its functional role via association 
studies.

Bioinformatician Ref NA1029
We are seeking a keen and able bioinformatician or computer 
scientistwith a strong desire to work in a cross-disciplinary 
laboratory environment.The ideal applicant would havestrong Unix/Linux 
skills, demonstrable experience with an object oriented programming 
language (such as OO Perl or Java), relational databases and knowledge 
of biological analysis pipelines.A degree or a strong interest in 
thelife sciences is highly desirable. The position offers experience in 
working with a diverse range of bioinformatic systems and datasets and, 
as such, would suit a candidate seeking broad experience and the 
opportunity to develop a varied set of professional skills.

Informal enquiries for both positions to Matthew Hurles 
([log in to unmask]) and Nigel Carter ([log in to unmask]).

Both posts are available for 3 years in the first instance. Benefits 
include 25 days annual leave, final salary pension scheme, optional 
private healthcare (on successful completion of probation period), 
permanent disability insurance, life assurance, childcare voucher 
scheme, on-site restaurant, café, gym and an active sports and social 
scene. 

To apply for this position please email your CV (including 2 referees) 
and current salary details, Quoting the appropriate reference to: 
 [log in to unmask]
Or post your application to: Human Resources Department, The Wellcome 
Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA

The closing date for applications is 18th November 2005
www.sanger.ac.uk