ROYAL STATISTICAL
SOCIETY
MANCHESTER LOCAL GROUP
A joint meeting with the Manchester Biostatistics
group on the theme
Bioinformatics
Wednesday 12th October 2005
NICK FIELLER
Gene Expression and Annotation
This talk will cover the statistical analysis of various forms of oligonucleotide
microarrays, involving very high dimensional data with limited numbers of
observations and poor replication, using ‘annotation’ (information on the genes
which could play a dual role in the analysis), and citations relating genes to a
Medical Subject Heading.
TOM NYE
Uncovering evolutionary history: new methods for inferring
phylogenies
Evolutionary relationships between species can be represented by a
phylogenetic tree, and there are a range of different statistical methods
available for inferring the phylogeny of a set of species given their DNA
sequences. We present an introduction to this area and look in more detail at a
new distance-matrix method.
MAGNUS RATTRAY
Propagating Measurement Uncertainty in Microarray Data Analysis
Microarrays, e.g. oligonucleotide arrays. can be used to simultaneously
measure the concentration of many species of RNA molecules within a sample
derived from a tissue of interest, but with many sources of experimental
uncertainty and noise. In this talk I will discuss approaches for dealing with this
uncertainty.
Venue: MANDEC (Manchester Dental Education Centre)
Higher Cambridge Street, Manchester.
Time: 2.00pm - 5.00pm (tea will be served about mid-
afternoon)
ALL ARE MOST WELCOME TO ATTEND!
Please e-mail Wendy Lamb ([log in to unmask]) if you will be
attending.
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