I was wondering if anyone knows the most appropriate way of handling this problem.
We have conducted and experiment with 42 rats which were divided into 7 groups.
First, the iron content of each of the 42 rats were taken for three consecutive days. Then, dextran was injected into the rats based on the weight of the rats. This was done to induce an iron overload. For three consective days again, the iron content in the urine and faeces were measured. Then an iron removal drug was given to the groups in different forms. Again, the iron content in the urine and faeces were measured for three consecutive days during the treatment and then for three days after the treatment.
My question is this:
1) I want the find out which groups were significantly different from one another.
2) Is there is signicant difference in iron removal during and after treatment for groups 4, 6 and 7?
I was told that this can't be a repeated measures. Since all the rats were not exposed to all the 7 treatments for iron removal. Is MANOVA acceptable here and if so, do I have to get a total for the three variables for each of the consecutive days for to use the variables in the program. Or should I resort to a one way ANOVA?
Isaac
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