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>Dear allstaters,
>
>We are planning for a PhD research project based on an observational
>follow-up design. The working title is "A study to evaluate and identify
>measures of the quality of stroke care". The main objective is to identify
>the important structure and process variables of stroke care and to
>estimate their influence on outcome variables (e.g. survival, disability,
>handicap and so on). The previous studies show that the incidence of
>stroke in the study area is 24 per month. The drop out rate per year is
>15% and the case fatality rate (death rate) within one year is 36%.
>
>We are thinking to recruit patients over 2-years and to measure the
>related structure and process variables of stroke care. Then to follow
>them up for one year and to measure the outcome variables.
>
>I am familiar with the sample size calculation for clinical trials but not
>for observational cohort studies. Any help, suggestion or reference
>regarding the appropriate minimum sample size determination will be highly
>appreciated.
>
>Regards,
>J
>Research Fellow
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