Dear Markus/Stephen
I use MAD (Median of Absolute Differences) as described in my book
Practical Statistics for the Analytical Scientist - The Royal Society of
Chemistry 1997 (unfortunately there is nothing on SAD). As it happens one
of my colleagues was using MAD only yesterday analysing missed hair lengths
and counts. Unfortunately I know very little on drug development hence I
didn't answer your [Markus] earlier message. I would like to ask [Stephen]
how you would define whether something is a standard term, e.g., MAD is
commonly used, Markus was interested in it and yet you were able to answer
his query.
Trevor Farrant
Senior Research Statistician
Gillette Advanced Technology Centre
Stephen Senn
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15/07/2004 13:04
Please respond
to Stephen Senn
Dear Markus,
There is a chapter on dose-finding in my book Statistical Issues in Drug
Development, Wiley 1997. that has some discussion of issues and references
to papers. I personally do not use SAD and MAD as terms and do not think
they are standard. I heard them used earlier in the week at the ECPM course
in Basle and if any of your colleagues were attending you might like to ask
them for notes.
Regards
Stephen
At 13:31 15/07/2004 +0200, Abt, Markus {PDMB~Basel} wrote:
>Dear all,
>
> is anybody aware of statistically oriented articles about SAD and MAD
>studies as they are done in early drug development. I would be
>interested in (more statistically oriented) articles or books dealing
>with any aspect or issues that arise during the planning or conduct
>phase of such studies. An internet search just led to case studies,
>which is not what I was looking for. My interest is in methodology, whey
>are they done the way we do them, what alternative designs are there,
>how many pts are really needed etc.
> Many thanks in advance for your help.
>
>Kind regards
>Markus
Stephen Senn
Professor of Statistics
Department of Statistics
15 University Gardens
<http://www.gla.ac.uk>University of Glasgow
G12 8QQ
Tel: +44 (0)141 330 5141
Fax: +44(0)141 330 4814
email [log in to unmask]
Private webpage: http://www.senns.demon.co.uk/home.html
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