Dear colleagues,
not an infrequent question in pharmacokinetic studies is when steady
state has been attained. I have seen exponential models of the type
C(t)=C0*(1-exp(-k*t)) being fitted to concentration data and then choose
"time to steady state" as the value where 90% of the estimate of C0.hat
is reached.
Would anybody be willing to share any ideas and or references with
regard to statistical approaches you have seen being used to determine
steady state, maybe even design considerations? What kind of
probabilistic or statistical statements are frequently made? After all,
in the end we might want to be "reasonably sure" that, at whatever
values we come up with, "most" patients have reached steady state under
the dosing regimens summarized.
Many thanks in advance for any information you can share.
Kind regards
Markus
PS Please let me know if anybody interested in an (anonymized) summary
of possible responses I get . . .
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