I was hoping someone on the list could provide reference(s) re estimating
sample size when the objective is estimation of the maximum tolerated dose
(dose escalation is within patients). I ran a search on medline but didn’t
find anything useful (the most relevant paper found didn't describe or
justify the sample size calculation) and Machin, Campbell et al. (where I
usually look first) doesn't cover it. Any info would be much appreciated.
Thanks.
Mike
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