MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS
29 September - 1 October 2004
This course will cover the statistical background to the mixed model
and will emphasise its practical application in medical data with
particular reference to clinical trials. All analyses will be
illustrated using SAS and lectures will be combined with practical
sessions in order to reinforce concepts. Topics covered include:
DAY 1
General concepts and underlying statistical theory
Use and interpretation of PROC MIXED
Multi-centre trials and meta-analysis
Consideration of issues such as biased standard errors,
significance testing and negative variance components.
DAY 2
Repeated measures trials
Random coefficients models
Crossover trials
More complex trial designs
Introduction to Bayesian methods.
DAY 3
Generalised linear mixed models
Mixed models for ordinal data
Use of SAS for fitting mixed models to non-normal data.
THE SPEAKERS
Robin Prescott
Robin is Director of the Medical Statistics Unit of The University of
Edinburgh and is Professor of Health Technology Assessment. He has been
working in the medical field for over thirty years and has a particular
interest in cross-over trials. He has wide experience of multi-centre
trials and of working with the pharmaceutical industry.
Helen Brown
Helen is a Principal Statistician within NHSScotland. She has twenty
years of practical experience as a medical statistician with experience
in both academic and commercial environments. She has a research interest
in the application of mixed models in the medical field.
The speakers are the authors of Applied Mixed Models in Medicine, in
the John Wiley Statistics in Practice series .
WHO SHOULD ATTEND
This course is directed at medical statisticians who wish to understand
the statistical background to mixed models and to carry out analyses
using SAS.
WHY ATTEND
Conventionally, clinical data is analysed using fixed effects models.
However, benefits can often be gained by using a mixed model. For
example: in repeated measures trials full allowance can be made for
the correlation occurring between the repeated observations even if
data are missing; in multicentre trials or meta analyses treatment
standard errors are more appropriately based on between centre/trial
variation (fixed effects standard errors are based on within centre/trial
variation); in crossover trials more accurate treatment means are often
achieved by combining within and between patient estimates. Previously
the use of these models has been limited by heavy computational
requirements and a lack of generally available software, but this is
now much less of a restriction with the introduction of suitable
procedures into well known packages such as SAS. As with any statistical
technique a firm understanding of the theoretical background is essential
to allow its effective application and to obtain a clear interpretation
of results.
COURSE FEES
Standard rate £795
Academic institutions and registered charities £495.
Fees include daily morning coffee, lunch, afternoon tea, a course
dinner and a delegate's pack including full course notes.
REGISTRATION AND FURTHER INFORMATION
To reserve your place(s), please complete the registration form on the
inside cover and fax or post it to:
Office of Lifelong Learning - CPD Unit
11 Buccleuch Place
Edinburgh EH8 9LW
Tel: 0131 651 1819
Fax: 0131 651 1746
Email: [log in to unmask]
Alternatively you can book online at:
www.lifelong.ed.ac.uk/cpd/courses
TERMS AND CONDITIONS
Payment should accompany your registration form. If invoiced, fees must
be paid in full by the day before the course is due to commence. Failure
to pay may result in attendance being refused.
For cancellations received in writing at least five working days before
the course commences, a 20% administrative charge will be made. After
this date, fees will not normally be refunded but places are fully
transferable.
The University of Edinburgh reserves the right to cancel or postpone the
course, in which case fees will be refunded in full. In the event of
cancellation, The University of Edinburgh will not be held liable for
registrants' travel or accommodation costs. All payments should be in
sterling. Please note that participants are responsible for payment of
any bank charges incurred.
VENUE
The course will take place in the Holiday Inn, Edinburgh-North, one
mile from the city centre and easily accessible from the main railway
station and airport.
ACCOMMODATION
Course participants have the opportunity to stay at the Holiday Inn,
Edinburgh-North at the reduced rate of £80 per night. All bedrooms in
the hotel have modem points. For further information please contact
Reservations on 0131 332 2442 quoting The University of Edinburgh.
Alternatively please contact our accommodation agency, Murray Accommodation.
Telephone: 08707 509808
Email: [log in to unmask]
or visit www.murray-accommodation.co.uk
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