Rather than comparing the event free rate at a certain time point between
treatment arms we prefer to use the time to event analysis because it
contains more detailed information and will usually lead to a more sensitive
comparison of the treatment arms. Is the power of the log-rank test (under
the assumption of a constant hazard ratio) higher when compared to the
Fisher exact test?
Is there any literature on the dichotomized analysis vs. the time to event
analysis in terms of gain/loss in power and interpretation of the analyses?
What about model assumptions such as constant hazard ratio, .... ?
Best regards,
Saghir
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