MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS
29 September - 1 October 2004
Medical Statistics Unit
The University of Edinburgh
This course will cover the statistical background to the mixed model and
will emphasise its practical application in medical data with particular
reference to clinical trials. All analyses will be illustrated using SAS
and lectures will be combined with practical sessions in order to reinforce
concepts. Topics covered include:
Day 1
* General concepts and underlying statistical theory
* Use and interpretation of PROC MIXED
* Multi-centre trials and meta-analysis
* Consideration of issues such as biased standard errors, significance
testing and negative variance components.
Day 2
* Repeated measures trials
* Random coefficients models
* Crossover trials
* More complex trial designs
* Introduction to Bayesian methods.
Day 3
* Generalised linear mixed models
* Mixed models for ordinal data
* Use of SAS for fitting mixed models to non-normal data.
THE speakers
Robin Prescott
Robin is Director of the Medical Statistics Unit of The University of
Edinburgh and is Professor of Health Technology Assessment. He has been
working in the medical field for over thirty years and has a particular
interest in cross-over trials. He has wide experience of multi-centre trials
and of working with the pharmaceutical industry.
Helen Brown
Helen is a Principal Statistician within NHSScotland. She has twenty years
of practical experience as a medical statistician with experience in both
academic and commercial environments. She has a research interest in the
application of mixed models in the medical field.
The speakers are the authors of Applied Mixed Models in Medicine, in the
John Wiley Statistics in Practice series .
Who should attend
This course is directed at medical statisticians who wish to understand the
statistical background to mixed models and to carry out analyses using SAS.
Why attend
Conventionally, clinical data is analysed using fixed effects models.
However, benefits can often be gained by using a mixed model. For example:
in repeated measures trials full allowance can be made for the correlation
occurring between the repeated observations even if data are missing; in
multicentre trials or meta analyses treatment standard errors are more
appropriately based on between centre/trial variation (fixed effects
standard errors are based on within centre/trial variation); in crossover
trials more accurate treatment means are often achieved by combining within
and between patient estimates. Previously the use of these models has been
limited by heavy computational requirements and a lack of generally
available software, but this is now much less of a restriction with the
introduction of suitable procedures into well known packages such as SAS.
As with any statistical technique a firm understanding of the theoretical
background is essential to allow its effective application and to obtain a
clear interpretation of results.
course fees
Standard rate £795
Academic institutions and registered charities £595.
Fees include daily morning coffee, lunch, afternoon tea, a course dinner and
a delegate's pack including full course notes.
Registration and further information
To reserve your place(s), please contact:
Office of Lifelong Learning - CPD Unit
11 Buccleuch Place
Edinburgh EH8 9LW
Tel: 0131 651 1819
Fax: 0131 651 1746
Email: [log in to unmask]
Alternatively you can book online at:
www.lifelong.ed.ac.uk/cpd/courses
Terms and conditions
Payment should accompany your registration form. If invoiced, fees must be
paid in full by the day before the course is due to commence. Failure to pay
may result in attendance being refused.
For cancellations received in writing at least five working days before the
course commences, a 20% administrative charge will be made. After this date,
fees will not normally be refunded but places are fully transferable.
The University of Edinburgh reserves the right to cancel or postpone the
course, in which case fees will be refunded in full. In the event of
cancellation, The University of Edinburgh will not be held liable for
registrants' travel or accommodation costs. All payments should be in
sterling. Please note that participants are responsible for payment of any
bank charges incurred.
Venue
The course will take place in the Holiday Inn, Edinburgh-North, one mile
from the city centre and easily accessible from the main railway station and
airport.
Accommodation
Course participants have the opportunity to stay at the Holiday Inn,
Edinburgh-North at the reduced rate of £80 per night. All bedrooms in the
hotel have modem points.
For further information please contact Reservations on 0131 332 2442 quoting
The University of Edinburgh.
Alternatively please contact our accommodation agency, Murray Accommodation.
Telephone: 08707 509808
Email: [log in to unmask]
or visit www.murray-accommodation.co.uk
<http://www.murray-accommodation.co.uk>
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Helen Brown
Principal Statistician
Information and Statistics Division, NHSScotland
Trinity Park House, Edinburgh
Tel: 0131 551 8304 (or 0131 554 1097, 07718 932096)
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