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Bioinformatician – Toxicogenomics – East Anglia AFB1001645
Permanent
c40k
PURPOSE STATEMENT:
Our client is actively seeking a bioinformatician to assist in developing
the toxicogenomics programme and provide expert statistical analysis and
interpretation from the microarray studies in support of the Disease
Processes Group in the Research and Development group, Risk
Characterisation Programme.
The programme combines the expertise of R&D in disease processes with the
molecular technologies available to examine changes in gene expression
associated with exposure to the companies byproducts.
These studies will lead to:
– a better mechanistic understanding of the harmful effects of the
company’s by-products
– identification of components which are potentially associated
with disease processes for the identification of risk reduction targets
– possible validation of in vitro alternatives to animal
inhalation studies by comparing responses to byproducts to those observed
in vivo
– identification of biomarkers of harm which may be useful for
more fully characterising the potential reduction in harm following product
modifications
Much of the information gained from this programme will be placed in the
public domain and used as a vehicle for scientific engagement
Principal Accountabilities
Provide the most up to date statistical analysis and biological
interpretation of data collected from the different microarray projects in
a form suitable for publication in peer reviewed journals.
As a senior member of the toxicogenomics team assist in developing the
strategy and formulating the experimental details of microarray studies.
As a member of the Management Group drive effective and efficient
management of the small toxicogenomics group and participate fully in the
general management to ensure that we meet the Company objectives.
To provide general statistical and genomics expertise to the other projects
to ensure efficient uses of resources and producing high quality science.
Knowledge, Skills & Experience
The position requires a PhD with at least 4 years post doctoral experience
(specialising in bioinformatics).
Several years experience in the statistical analysis of microarray data and
interrogation of public databases to provide a biological interpretation of
the changes observed in gene expression. (The biological interpretation of
the data using statistical methods is more important than the ability to
write and develop new statistical techniques.)
A good working (hands on) knowledge of microarray technology, preferably
with the Affymetrix
system, within the context of human diseases.
Ability to explain complex statistical techniques to the “lay person” but
at the same time communicate to leaders in the field and be able to
contribute to the publication of the results in peer reviewed scientific
journals.
– Effective leadership and team building skills and the ability to
work across two sites
– Good communication skills to Senior Management levels
– Ability to motivate and inspire teams
Key Success Factors
Analysis and conclusions from the data analysis of the microarray studies
recognised as leading science and used to generate further work by
Acceptance by regulatory bodies as providing constructive data in the risk
characterisation dialogue.
Targets are met on time with the group working effectively as a team
Working Relationships
Programme Managers in R&D
External academic groups in the biomedical/genomics field
External consultants as part of the advice given to the programme
To Apply:
If you would like to be considered for this role, please contact Alison
Fisher at Hudson Shribman, outlining your particular skills and experience
and their relevancy to this post.
Please either call on 020 7269 0900, or reply via email, entering the job
title and reference code in the subject field to
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