> I am completely new to VBM. I have a group of patients (n=40) and healthy
> matched controls (n=10) that I want to compare using VBM. However, only
> partial high-res T1's exist for these 50 subjects (e.g., temporal lobe
> slices). Is it still feasible to employ VBM to analyze these data? Could
> I create my template using the data/slices I do have? Any assistance would
> be greatly appreciated...
It might worki, but I'm not sure without trying. If you have enough brain
coverage to achieve sucessful spatial normalisation, then you should have a
good chance.
There is one thing to watch out for though. I'm sure that the brain coverage
is likely to differ among subjects, so a bit of extra processing may be
necessary so that you don't see differences due to this. It might be a good
idea to mask out these differences before the data are smoothed. The
following may work:
P=spm_get(Inf,'*.IMAGE','Select pre-processed images');
spm_mask(P,P, 0);
To save disk space, you may also want to try reducing the bounding box for the
spatially normalised images.
Best regards,
-John
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