Hi Donghoon.
For masking I do not think data type is important. Really a mask is a binary image of 0 and 1, so the image type really makes no difference. The 1's and 0's will still be 1's and 0's whether the image is uint8 or uint16, etc. However, what is important is that the mask you are applying is the same size volume as the image you are applying it to and that it is in registration with that image.
Hope this helps.
-John West
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