Dear SPM list:
We are interested in looking at brain changes in normal aging and different
neurodegenerative illnesses (mainly Alzheimer´s Disease and Mild Cognitive
Impairment), and would like to construct a template in this regard. We would
appreciate some help about the following issues:
1) As far as I understand it correctly, the theory is that one should use
the biggest number of subjects (if possible all) included in a study to
construct a template for the optimised version of VBM.
Does this imply that once a template is created (let´s say including normal
aging, AD and MCI), it is not appropiate to use it as a template for a
different population (let´s say a slightly different population of MCI, as
an example)?
2) Regarding template creation: Would anybody be willing to share a protocol
and/or batch for SPM?
3) Does a number of about 70 subjects from 3 different groups (about 40
normal aging, 15 AD, and 15 MCI) seem reasonable for a template?
Many thanks in advance,
Beatriz Gómez-Ansón
Consultant Neuroradiologist
Hospital Clinic, Barcelona (Spain)
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