Medical Statistics Unit
The University of Edinburgh
MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS
PROC MIXED AND BEYOND
1-3 October 2003
Organised by the Office of Lifelong Learning
www.lifelong.ed.ac.uk/cpd/courses <http://www.lifelong.ed.ac.uk/cpd/courses>
COURSE CONTENT
This course will cover the statistical background to the mixed model and
will emphasise its practical application in medical data with particular
reference to clinical trials. All analyses will be illustrated using SAS and
lectures will be combined with practical sessions in order to reinforce
concepts. Topics covered include:
DAY 1
* General concepts and underlying statistical theory
* Use and interpretation of PROC MIXED
* Multi-centre trials and meta-analysis
* Consideration of issues such as biased standard errors, significance
testing and negative variance components.
DAY 2
* Repeated measures trials
* Random coefficients models
* Crossover trials
* More complex trial designs
* Introduction to Bayesian methods.
DAY 3
* Generalised linear mixed models
* Mixed models for ordinal data
* Use of SAS for fitting mixed models to non-normal data.
Who should attend
This course is directed at medical statisticians who wish to understand the
statistical background to mixed models and to carry out analyses using SAS.
Why attend
Conventionally, clinical data is analysed using fixed effects models.
However, benefits can often be gained by using a mixed model. For example:
in repeated measures trials full allowance can be made for the correlation
occurring between the repeated observations even if data are missing; in
multicentre trials or meta analyses treatment standard errors are more
appropriately based on between centre/trial variation (fixed effects
standard errors are based on within centre/trial variation); in crossover
trials more accurate treatment means are often achieved by combining within
and between patient estimates. Previously the use of these models has been
limited by heavy computational requirements and a lack of generally
available software, but this is now much less of a restriction with the
introduction of suitable procedures into well known packages such as SAS. As
with any statistical technique a firm understanding of the theoretical
background is essential to allow its effective application and to obtain a
clear interpretation of results.
course fees
A special rate is available for bookings made by Friday 27 June.
Early booking rate £695
Standard rate £795
A limited number of places will be available upon enquiry for those from
registered charities/academic institutions at the reduced rate of £495.
Fees include daily morning coffee, lunch, afternoon tea, a course dinner and
a delegate's pack including full course notes.
The speakers
Robin Prescott is Director of the Medical Statistics Unit of The University
of Edinburgh and is Professor of Health Technology Assessment. He has been
working in the medical field for over thirty years and has a particular
interest in cross-over trials. He has wide experience of multi-centre trials
and of working with the pharmaceutical industry.
Helen Brown is a Principal Statistician for the NHS in Scotland. She has
nearly twenty years of practical experience as a statistician including five
spent in the pharmaceutical industry.
The speakers are the authors of Applied Mixed Models in Medicine, in the
John Wiley Statistics in Practice series.
Venue
The course will take place in the Holiday Inn, Edinburgh-North, one mile
from the city centre and easily accessible from the main railway station
and airport.
ACCOMODATION
Course participants have the opportunity to stay at the Holiday Inn,
Edinburgh-North at the reduced rate of £75 per night. All bedrooms in the
hotel have modem points. For further information please contact the
Reservations department on 0131 332 2442 quoting University of Edinburgh.
Alternatively please contact our accommodation agency: Murray
Accommodation, telephone 08707 509808, or visit
wwwmurray-accommodation.co.uk
Registration and further information
To reserve your place(s), please complete the
registration form on the inside cover and fax or post it to:
Office of Lifelong Learning - CPD Unit
11 Buccleuch Place
Edinburgh EH8 9LW
Tel: 0131 651 1819
Fax: 0131 651 1746
e-mail: [log in to unmask]
Alternatively you can book online at:
www.lifelong.ed.ac.uk/cpd/courses
TERMS AND CONDITIONS
Payment should accompany your registration form. If invoiced, fees must be
paid in full by the day before the course is due to commence. Failure to pay
may result in attendance being refused. For cancellations received in
writing at least five working days before the course commences, a 20%
administrative charge will be made. After this date, fees will not normally
be refunded but places are fully transferable. The University of Edinburgh
reserves the right to cancel or postpone the course, in which case fees will
be refunded in full. In the event of cancellation, The University of
Edinburgh will not be held liable for registrants' travel or accommodation
costs. All payments should be in sterling. Please note that participants are
responsible for payment of any bank charges incurred.
_________________________________________________________________
Common Services Agency Disclaimer
The information contained in this message may be confidential or legally privileged and is intended for the addressee only. If you have received this message in error or there are any problems please notify the originator immediately. The unauthorised use, disclosure, copying or alteration of this message is strictly forbidden.
_________________________________________________________________
|