In article <[log in to unmask]>,
   <[log in to unmask]> wrote:
> Can you tell me where some of the original research was done -
> I'd like to look it up. I wasn't aware of the 10% at all
> (obviously... or I wouldn't have been confused by my patient
> potentially being one of them!) This case has provoked my
> interest... I feel a clinical topic review coming on :-)

> Sarah Spencer
> SpR, Oxford Region

Much of the early research on paracetamol poisoning was done by Laurie
Prescott and others in Edinburgh, at the Regional Poisoning Treatment
Centre at Edinburgh Royal Infirmary. Laurie Prescott described one of
the first cases of liver damage due to paracetamol (in 1966 when he was
at Aberdeen), developed the first effective treatment (cysteamine) and
the paracetamol treatment line, and also introduced N-acetylcysteine
which has been the standard treatment for more than twenty years.

If you want to study paracetamol poisoning in detail for a clinical topic
review I would suggest that you look at Laurie Prescott's book "Paracetamol
(Acetaminophen) a critical bibliographic review" (published by Taylor &
Francis, second edition 2001, ISBN 0415258456, 150 UK pounds) in which he
reviews all aspects of paracetamol. More details of this book are available
on the BMJ Bookshop website or from the publisher.

I think that some aspects of paracetamol poisoning could make an
interesting clinical topic review for the FFAEM exam.

Robin Illingworth

(1977-1979 : Medical Registrar,
             Regional Poisoning Treatment Centre, Edinburgh.

Now : A&E Consultant, St James's University Hospital, Leeds
and an examiner for the FFAEM)

--
Robin Illingworth, Leeds ([log in to unmask])
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