Dear SPMers
We were wondering how to go about identifying regions that show significant reductions in activation.
1) We imaged subjects during exposure to stimulus A (to produce anxiety), then..
2) exposed Ss to an intervention that reduced self-reported anxiety to A.
3) We then imaged Ss again while exposing them stimulus A.
We hypothesize that our intervention will reduce activation in our ROI.
Using a RFX paired t-test, we know that the contrast preA - postA shows regions with sig greater activation in preA, but can one say that these same regions were also ones that showed sig reductions in postA?
(My gut says no, but I'm unsure what my next step should be).
Bungling in Baltimore,
Mike Schlund, Ph.D.
Johns Hopkins SOM
Kennedy Krieger Institute
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