Dear Allstatters,
I am currently helping in setting up a short course in clinical trials
methodology. I am now dealing with the issue of overpowered trials and the
difference between clinical relevance and statistical significance. I would
like to corroborate my points with some examples of published overpowered
clinical trials which findings were significant but of poor clinical
relevance. Also a review would do.
Have you any good reference to suggest for such an example?
Thanks in advance.
Roberto Ferrara
Novartis Farma
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