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>>-------------------------------------------
>>
>>Postdoctoral positions for a statistician, a database programmer, and
>>an application programmer available
>>
>>GENSCEND is an initiative based at the University of London and funded
>>by the Wellcome Trust. Its aim is to analyse the transcriptome of
>>single motor and olfactory neurons and reconstruct gene regulatory
>>events during critical stages of development in mouse and chick
>>embryos. The primary analysis tools are single cell microarrays and
>>computational methods of analysing microarray data and reconstructing
>>regulatory networks.
>>
>>We are looking for a statistician for the microarry data analysis and
>>gene regulatory network reconstruction. A database programmer will
>>design and run the database collating microarray data and other
>>relevant data for a functional analysis (eg. genomic data,
>>transcription factors). The main task of the application programmer is
>>to provide interfaces and algorithms for data submission, analysis
>>tools, and the communication between the 5 different sites of the
>>consortium.
>>
>>For more details please have a look at the job descriptions below or
>>at http://genscend.cryst.bbk.ac.uk
>>
>>For further questions please contact
>>Lorenz Wernisch, email: [log in to unmask]
>>
>>CVs (also per email) should be send to
>>
>> GENSCEND Initiative
>> c/o Maureen Austin
>> School of Crystallography
>> Birkbeck College
>> Malet Street
>> London WC1E 7HX
>> email: [log in to unmask]
>>
>>
>>----------------------------------------------------
>>
>>The following 3 postdoctoral positions are available in the group of
>>Lorenz Wernisch (http://www.cryst.bbk.ac.uk/wernisch) at Birkbeck
>>College, University of London. Candidates should have a PhD or
>>extensive work experience in one of the areas of mathematics,
>>statistics, computer science, or physics.
>>
>>
>>STATISTICIAN
>>
>>Two areas of analysis are central to the project: the analysis of gene
>>expression data and the reconstruction of gene regulatory
>>networks. The task is to mine the chip data for statistical signficant
>>changes and to build hypothetical networks based on the correlation
>>structure in the data and prior knowledge from other sources. The
>>experimental groups in the consortium can then test hypotheses about
>>specific relations of genes, and the results of the experiments will
>>be incorporated in the network building. The overall goal is the
>>construction of a detailed computational model of gene regulatory
>>processes responsible for the developmental differentiation in
>>neuronal cells.
>>
>>The applicant should have a thorough knowledge of standard statistical
>>analysis techniques as well as experience in parameter estimation for
>>large data sets and complex models (eg by MCMC). Microarray analysis
>>and regulatory network reconstruction are an area of very active
>>research and an ability to do independent research is therefore
>>mandatory.
>>
>>The post is for 3 years (extension possible) on level 3 of the
>>Wellcome Trust scale for research assistants (about 30,000 GBP per
>>year, for details see the Wellcome Trust Levels scales,
>>http://www.wellcome.ac.uk/en/images/levels2001_5684.pdf).
>>
>>
>>DATABASE PROGRAMMER
>>
>>The primary task of the database programmer is the design and
>>maintenance of a database for the storage of gene expression data and
>>other genomic resources that support gene expression analysis. The
>>database will be the primary repository for data generated and
>>analyses performed by all groups of the consortium. Schemas for such
>>microarray databases are publicly available but need adaptation to our
>>particular analysis approach, which is based an novel statistical
>>analysis methods and the reconstruction of regulatory gene
>>networks. This entails that data on genome sequences, transcription
>>factors, gene and protein interaction, and metabolic networks need to
>>be kept locally and updated as well. The programmer is also expected
>>to contribute to research how best to integrate and interpret such
>>heterogeneous data sources.
>>
>>The applicant should have experience in database design and
>>maintenance. We prefer open source databases such as PostgreSQL in a
>>Unix environment. Some knowledge in Java is required too, which is the
>>preferred language for linking input and analysis tools to the
>>database.
>>
>>The post is for 3 years (extension possible) on level 3 of the
>>Wellcome Trust scale for research assistants (about 30,000 GBP per
>>year, for details see the Wellcome Trust Levels scales,
>>http://www.wellcome.ac.uk/en/images/levels2001_5684.pdf).
>>
>>
>>APPLICATION PROGRAMMER
>>
>>The task of the programmer is to write interface programs for
>>submission of and the access to the data in the database (see
>>description for the database programmer), for access to the
>>statistical analysis tools, and for communication between the groups
>>in the consortium. Such interfaces need to be tailored to the needs of
>>researchers whose primary research tool is not the computer. A
>>challenging aspect of the project is the integration of advanced
>>analysis tools for gene expression data and the visual display of
>>analysis results. Mathematical packages like R, Matlab, or Maple, and
>>microarray analysis software need to be integrated too.
>>
>>The applicant should have experience in programming user interfaces in
>>Java and HTML and will have to work closely with end-users to tune
>>these interfaces according to their needs.
>>
>>The post is for 3 years on level 3 of the Wellcome Trust scale for
>>research assistants (about 30,000 GBP per year, for details see the
>>Wellcome Trust Levels scales,
>>http://www.wellcome.ac.uk/en/images/levels2001_5684.pdf).
>>
>>
>>-----------
>>School of Crystallography Tel +44 (0)20 7631 6831
>>Birkbeck College Fax +44 (0)20 7631 6803
>>University of London [log in to unmask]
>>Malet Street
>>London WC1E 7HX, UK Room E321/3078
>>-----------
>
>--------------------------------------------------------------------------------------------------
>Andrew McMullan Phone:0141-330 2474
>Statistics Department Email:[log in to unmask]
>University of Glasgow
>University Avenue
>Glasgow
>G12 8QQ
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>
>
>
>

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Andrew McMullan Phone:0141-330 2474
Statistics Department Email:[log in to unmask]
University of Glasgow
University Avenue
Glasgow
G12 8QQ
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