At twenty quid a vial, cost is one good reason.
Mark Slade
-----Original Message-----
From: [log in to unmask] [mailto:[log in to unmask]]
Sent: 15 October 2001 15:44
To: [log in to unmask]
Subject: Flumazenil, Sedation and Fits
Recently while reducing bilateral shoulder 'erecta' dislocations (don't ask)
under a bit of Midazolam and opiate I was challenged by a colleague as why I
was not wanting to use Flumazenil to simply reverse the Midaz as soon as the
procedure was over.
I gave the standard 'Fit Risk' answer but was then asked to prove it....
So trying to be the good evidence based practitioner i went to Medline and
searched
around the subject. To my surprise their are papers that not only document
Flumazenil
causing fits, usually in relation to mixed ODs, but several advocating its
USE
as an ANTI-epileptic ( Oral flumazenil in the treatment of epilepsy. Annals
of Pharmacotherapy.29(5):530-1,1995May Reisner-Keller LA et al)
So does anyone have a reference/evidence for why we don't use it for simply
waking uncomplicated sedated patients up?
Cheers
Peter A Cutting
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