It's all to do with the receptor. I believe buprenorphine has its greatest effect at the sigma receptor, while morphine is a classic pure mu
receptor agonist. Unfortunately, naloxone is a weak and incomplete antagonist at the kappa and sigma receptors, while being extremely
effective at the mu receptor. I'm sure Professor John Henry will be along shortly but I think that's the story.
Best wishes,
Rowley Cottingham
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