Can someone please explain to me why gray matter changes in the amygdala
(and hippocampus) cannot be identified using VBM and SPM99? I have read the
Woermann et al paper that describes visibly evident hippocampal damage in
epileptic patients that was not detected using VBM. The authors reason that
small abnormalities are excluded due to normalization, segmentation, and
smoothing. Although that makes sense to me - it doesn't make sense that the
hippocampal damage that could be seen with the naked eye could not be
detected with this method. They also state that automatic segmentation and
voxel-by-voxel comparison of structural MRI is not suitable for
investigating the amygdala and hippocampus. Is it just these two regions?
Why just these two regions? I would greatly appreciate any references or
help in resolving this issue. Thanks all, teri-)
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