Are there any serious disadvantages for coregistration (motion correction)
and Talairach normalization if one only collects slices less than a whole
brain? (We want to image the auditory cortex.) My impression is that the
following obstacles might be an issue:
(1) For motion correction, "out of plane" motion leads to motion in and out
of the "cylinder" of (axial) slices, and perhaps the coreg. algorithm might
not deal with that well. (To restate that, if you collect only a subset of
slices, out-of-plane movement means that the actual tissue imaged varies at
the "top" and "bottom" of the cylinder.)
(2) For Talairach normalization, one might have to adjust the template with
the whole brain by masking out the parts not imaged, etc.
Best wishes,
Stephen Fromm, PhD
NIDCD/NIH
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