Would this lead to the presumption that obese indidividuals may be thus
further predisposed to fractures? It would be interesting to compare the
increased bone density caused by increased weight borne by the bones to the
decreased bone density caused by a high-fat, high cholesterol diet
Owen Sant' Angelo
B.Sc. (Hons) Physiotherapy
----- Original Message -----
From: <[log in to unmask]>
To: <[log in to unmask]>
Sent: Saturday, December 23, 2000 2:52 AM
Subject: Fats & Osteoporosis
> A diet high in saturated fats may lead not only to obesity and heart
disease
> but also to osteoporosis.
>
> Mice fed a high-fat, high cholesterol diet for seven months lost very
large
> amounts of minerals from their bones, as well as 15 percent of the bone
from
> their hind legs, a team at the University of California, Los Angeles,
> reported recently. Previously, the same research team had found that mice
> fed the high-fat diet, which raises their cholesterol, had many fewer
> bone-forming cells than mice in a normal diet, suggesting that high
> cholesterol may decrease overall bone production. According to some
> workers, since the structures of bone and artery are very similar,
> osteoporosis and heart disease may both be caused by an inflammatory
response
> in the body, associated with high cholesterol levels.
>
> In this respect, however, we need to note that elevation of cholesterol
> levels may not simply be associated with intake of saturated fats, but
also
> with other factors, such as the ingestion of refined carbohydrates. It
would
> be interesting to ascertain if the incidence of osteoporosis is also
> associated with very elevated calorie intakes, irrespective of source.
>
> Here is an abstract of the paper from which this information was derived:
>
> ------------------------
>
> Parhami F, Garfinkel A & Demer LL Role of lipids in osteoporosis.
> Arterioscler Thromb Vasc Biol 2000 Nov; 20(11):2346-8
>
> Cardiovascular disease and osteoporosis together account for most of the
> morbidity and mortality in our aging
> population despite significant improvements in treatment. Recently,
> converging lines of evidence suggest that
> these 2 diseases share an etiologic factor -that hyperlipidemia
contributes
> not only to atherosclerotic plaque
> formation, but also to osteoporosis, following a similar biologic
mechanism
> involving lipid oxidation. In vitro
> studies indicate that lipid products of oxidation promote osteoblastic
> differentiation of vascular cells and inhibit
> such differentiation in bone cells. Ex vivo, in vivo, and clinical studies
> further suggest that lipid-lowering
> agents reduce both atherosclerotic calcification and osteoporosis. Whether
> lipid-lowering agents reduce
> osteoporosis directly or indirectly through lipid reduction remains
> controversial.
>
> -------------------------
>
> Dr Mel C Siff
> Denver, USA
> [log in to unmask]
> http://www.egroups.com/group/supertraining
>
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