At 07:59 PM 11/07/00 +0100, you wrote:
>Chest marCH 2000;117:728-733.
(Liberally re-translated from French)
Deleterious effect of high concentration oxygen on acutely exacerbated
asthmatics
Researchers from the University Hospitals of Cleveland testing a group of
37 admissible patients (32 women; 43±2,7 yo) FEV1 of 49,1±3,6% of
theoretical values. Patients were hypocapnic & hypoxic (PaCO2/O2 from
36,8±1,1/70,2±2,5 mm Hg).
They received100% oxygen via NRM for 20 minutes.
A repeat ABG & pulmonary function test was repeated at the end of the 20
minutes
A statistically significant increase in the PaCO2 in 25 patients (67,6%).
No significant physiological changes were observed on 15 of the Pts (40,5%
of Pt total),
With a PaCO2 pressure gradient of 5,9mmHg (p<0,0001).
The PaCO2 was more significant on the more compromised Pts
showing a reverse relation between FEV1 :& PaCO2
Administration of 100% O2 to Pt with Severe airway obstruction would bring
on clinicaly significant negative effects to asthmatic in respiratory
distress.
This phenomena as not been observed on stable Pt with moderate obstructions
. Chest mars 2000;117:728-733.
Charles Brault EMT-P
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