Dear Jenny:
>
>As far as I can see, a REGIONALLY-specific task x drug interaction cannot
>be explained by a non-specific (ie. not regionally specific) effect of drug
>on the neurovascular pattern. In other words, to demonstrate a drug x task
>interaction (from which one can make cognitive inferences) the areas
>activated/deactivated by the interaction term should not be identical to
>those produced by the main effect of the task.
>
Of course, a 'REGIONALLY-specific task x drug interaction' is, by
definition, regionally specific. However, it may not necessarily be
metabolic, or 'cognitive'. For example, vascular innervation may be
regionally specific, or CBV may be different, giving rise to BOLD signal
changes that are only detectable in a particular region. Such effects would
be regionally specific, yet possibly uninteresting if not indicative of
local neuronal metabolic activation.
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