| We are currently using the SPM voxel-based method to look at gray
| matter density differences between a clinical population and
| controls. Recently, reviewers have asked if this approach has been
| validated against more conventional volumetric structural approaches.
|
| Basically we're wondering if the segmentation method used in SPM to
| separate gray/white tissues been validated?
|
| Any references would be very helpful.
There is some evaluation of the SPM99 segmentation (using simulated
images from Montréal) in the following:
J. Ashburner & K. J. Friston (2000): "Voxel-Based
Morphometry - The Methods." NeuroImage 11:805-821
It may also be worth taking a look at:
I. C. Wright, Z. R. Ellison, T. Sharma, K. J. Friston,
R. M. Murray & P. K. Mcguire (1999): "Mapping of grey
matter changes in schizophrenia." Schizophrenia Research 35:1-14
Best regards,
-John
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