Hello all,
Can anyone tell me how to use SPM96 to do a group analysis with
fixed-effect mode together with conjunction analysis as suggested by
Friston, Holmes, and Worsley (1999)?
I have an fMRI study with a group of only six subjects. Each subject
performed four experimental conditions/tasks (A, B, C, D) in a box-car
design with D (control condition) alternating with one of the other three
conditions in each run as follows:
Run 1: D A D A D A D A
Run 2: D B D B D B D B
Run 3: D C D C D C D C
Each run was repeated three times for every subject. Now, I want to
see if
the cortical area(s) activated in a condition is statistically reliable
across subjects. Because there are too few subjects in the group,
random-effect model is not appropriate for the analysis. According to
Friston, Holmes, and Worsley (1999), the fixed-effect model together with
conjunction analysis is a good way to determine reliable activations when
there is a small group of subjects. How do I use SPM96 to perform the
analysis?
Many thanks for your help.
Ben
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Benjamin Xu, Ph.D.
ERB/NINDS
The National Institutes of Health
5N250 Building 10 Center Dr.
Bethesda, MD 20892
Phone: (301)435-8542
Fax: (301)402-2871
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