UNIVERSITY OF EDINBURGH
Office of Lifelong Learning in association with
Medical Statistics Unit
presents two courses
DESIGN AND ANALYSIS OF CLINICAL TRIALS
15-17 May 2000
and
MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS
9-21 June 2000 and 27-29 September 2000
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DESIGN AND ANALYSIS OF CLINICAL TRIALS 15-17 May 2000
Course content:
Basics of clinical trial design
- randomisation
- avoidance of bias
- ethical issues
Types of trial design
- parallel groups
- cross-over trials
- sequential methods
Sample size
Explanatory vs pragmatic trials
Regulatory/organisational aspects
Analysis of parallel group studies
Cross-over trials
- design and analysis aspects
- two period trials
- multi-period trials
N-of-1 trials
Trials for bioequivalence
Use of baseline values
Interpretation of results
- multiple testing
- subgroup analysis
- published papers
Introduction to unusual and advanced methods of design and
analysis
The Speakers
---------------------
Robin Prescott is Director of the Medical Statistics Unit. He has
been working in the medical field for thirty years and has a
particular interest in cross-over trials. He has wide experience of
multi-centre trials and of working with the pharmaceutical industry.
Gordon Murray is Professor of Medical Statistics at the University
of Edinburgh. He has over twenty years of experience of
collaborating in clinical trials with medical colleagues, the
pharmaceutical industry, and drug regulatory authorities. Areas of
particular interest include trials in cardiovascular medicine and
clinical neurosciences.
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MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS
19-21 June 2000 and 27-29 September 2000
General concepts and underlying statistical theory
Use and interpretation of PROC MIXED
Multi-centre trials and meta-analysis
Consideration of issues such as biased standard errors,
significance testing and negative variance components
Repeated measures trials
Random coefficients models
Crossover trials
More complex trial designs
Introduction to Bayesian methods
Generalised linear mixed models
<Mixed models for ordinal data
Applications in a range of designs
Use of SAS for fitting mixed models to non-normal data
The Speakers
--------------------
Robin Prescott (as above)
Helen Brown is Principal Statistician of the Scottish Cancer
Intelligence Unit of the NHS in Scotland. She has fifteen years
practical experience as a statistician including five spent in the
pharmaceutical industry and seven in the Medical Statistics Unit.
The speakers are the authors of the new book in the John Wiley
Statistics in Practice series 'Mixed Models in Medicine'.
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Fees
--------
Each course costs £695, or £595 per person if the multiple booking
discount applies. A multiple booking discount of £100 per
delegate is offered to companies or delegates who take up three
or more places from the 2000 Medical Statistics Unit courses.
This offer is restricted to bookings made at the same time and is
valid for companies sending three or more delegates on both
courses.
Fees include daily morning coffee, lunch, afternoon tea, a course
dinner and a delegate's pack including full course notes.
A limited number of places will be available on enquiry to those
from academic institutions at the reduced rate of £395.
For further details and a registration form please contact
Lisa Ellis,
Office of Lifelong Learning,
11 Buccleuch Place,
Edinburgh EH8 9LW
Tel: 0131 651 1180
Fax 0131 651 1746
email: [log in to unmask]
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