You should check the caeruloplasmin levels. Aceruloplasminaemia can cause
this picture due to ferroxidase deficiency. (See ZL Harris, LW Klomp, and JD
Gitlin. Aceruloplasminemia: an inherited neurodegenerative disease with
impairment of iron homeostasis Am J Clin Nutr 1998 67: 972-977)
-----Original Message-----
From: Huw Griffiths [mailto:[log in to unmask]]
Sent: 28 November 2000 10:06
To: [log in to unmask]
Subject: L/H-type Ferritin
One of our physicians has been investigating a 51-year old woman
for possible iron overload. Serum Ferritin 2025 mcg/L (15-233). However,
serum Fe/TIBC normal, LFTs normal, Liver biopsy & genetic studies
not consistent with haemochromatosis. He has asked if L and H-type
serum ferritin concentrations can be measured. He is considering
an autosomal dominant condition in which hyperferritinaemia is associated
with cataract formation, in which ferritin is composed mostly of
the L-type subunits. Can anyone help/advise on the determination
of ferritin H/L subunits?
Thanks
--
Huw Griffiths
Huddersfield Royal Infirmary UK
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