THE CAMBRIDGE STATISTICS DISCUSSION GROUP
Thursday 8th February 2001 7:15 for 7:45
The Senior Parlour,
Gonville and Caius College,
Trinity Street,
Cambridge
Some recent progress in the design of regulatory toxicity studies
Graham Healey,
Huntingdon
Abstract:
Regulatory toxicology is a wide-ranging area today. A brief review of three
of the major areas, Bulk Chemicals, Agrochemicals and Pharmaceuticals, will
be presented. Each area involves whole programmes of tests, and current
developments with a statistical interest will be discussed for some of the
tests employed. Examples may include curve-fitting for degradation and
bioaccumulation studies, the design of acute toxicity studies, progress in
the search for in vitro replacements, the increased sophistication of
immunological tests, the analysis of mesocosm studies for the assessment of
aquatic community disruption, the relevance of toxicokinetic data and the
design and analysis of reproductive and tumour studies.
The overall aim will be to illustrate to what extent statistical design and
analysis are currently involved in toxicology today.
Speaker:
After graduating in Zoology and Applied Entomology at Imperial College
(1974), Graham changed tack and obtained an MSc in Biometry at Reading
University (1977). His first job was as Lecturer in Agricultural Statistics
in Malawi (1978), where he pursued the local wildlife. He then
returned to the UK to join the pharmaceutical Company, G.D.Searle, as
statistician in charge of preclinical support, in 1986 transferring to
Searle's development site in Belgium. He finally returned home in 1992 to
become Head of Statistics in Huntingdon providing support to the
departments of toxicology, pathology, drug metabolism, cell biology,
environmental fate and clinical research. Graham has been a member of PSI
(Statisticians in the Pharmaceutical Industry) for over 20 years and has
given many talks and organized many meetings on pre-clinical topics.
Directions: Enter the college by the front entrance on Trinity Street
opposite St. Michael's church. Pass the Porter's lodge on your right.
Turn right and follow the quadrangle around passing through the tunnel
in the far righthand corner situated by 'V' entrance. Carry straight on
for 28 yards till 'D' entrance appears on your right. Go through 'D'
entrance and up two flights of the stairs immediately in front of you.
The Senior Parlour is located to the left at the top of the second flight.
Parking at the college is very restricted. Free parking (after 5pm) is
available on Queen's Road by the college "backs". A pathway (Garret Hostel
Lane) leads from the road across the river and terminates at the back of
the college.
Next Meetings:
PLEASE NOTE CHANGE OF MARCH SPEAKER:
8th March - Alistair Murray (British Antarctic Survey) on 'How many krill
are in the sea?'
5th April - Judith Quinlan (SmithKline Beecham).
10th May - Jennifer Potts (Cognition and Brain Sciences Unit).
Supper: Some members eat regularly in the University Centre before
each meeting at 6-15. Feel free to join them.
Subscriptions: of 4 pounds per member are now due for the 2000-2001 session.
Cheques should be made payable to Robert Milroy and may be posted
to the secretary at the address below.
Secretary: Peter Watson, MRC Cognition and Brain Sciences Unit,
15 Chaucer Road, Cambridge CB2 2EF;telephone 01223 355294 Extension 380;
E-mail [log in to unmask]
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